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ONE PUPIL BIGGER THAN THE OTHER ANXIETY SKIN

Dosages of 30 mg/day for at least one week may be desirable initially to improve tolerance to the effects of Cymbalta.Do not open the capsule and sprinkle on foods or liquids, because this may affect the way the contents of the capsule are absorbed. Swallow Cymbalta capsules whole, do not crush or chew. Cymbalta is a delayed-release product.Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties however, it has been associated with a discontinuation syndrome on withdrawal even when tapered.Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. May interact with several other drugs including those metabolized by cytochrome p450 2D6 or 1A2 enzymes (such as nortriptyline or flecainide). May not be suitable for people with a history of seizures. May trigger an angle-closure attack in people with glaucoma. May worsen blood sugar control in people with diabetes.There have been reports of fatal liver failure associated with Cymbalta use. Avoid in people with severe kidney or liver disease.

The dosage of Cymbalta needs to be reduced in people with mild to moderate kidney or liver disease.

May cause a lowering of total body sodium (called hyponatremia) elderly people or people taking diuretics or already dehydrated may be more at risk.

May increase the risk of bleeding caution when using other drugs that increase bleeding risk (such as aspirin and NSAIDs).

May also increase blood pressure in some people.

May cause a lowering of blood pressure - this may be particularly noticeable when going from a sitting to a standing position and increase the risk of falls.

May precipitate a manic episode in people with undiagnosed bipolar disorder.

Interaction or overdosage may cause serotonin syndrome (symptoms include mental status changes [such as agitation, hallucinations, coma, delirium), fast heart rate, dizziness, flushing, muscle tremor or rigidity, and stomach symptoms (including nausea, vomiting, and diarrhea).

Symptoms may include anxiety, headache, dizziness, diarrhea, abnormal sensations such as pins and needles, irritability, insomnia, increased sweating, and tiredness.

Associated with a discontinuation syndrome if stopped abruptly or even when tapered.

An increased risk of suicidal thoughts, especially in young adults under the age of 24 (similar to other antidepressants).

ONE PUPIL BIGGER THAN THE OTHER ANXIETY SKIN

Severe skin reactions and urinary retention have also been reported with Cymbalta. Most people experience side effects with Cymbalta and one in six people stop taking the drug because of them.

Drowsiness, insomnia, nausea, headache, dry mouth, constipation, and dizziness.

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Cymbalta is available as a generic under the name duloxetine.

May be used to relieve pain associated with fibromyalgia and in the treatment of chronic musculoskeletal pain.

May relieve nerve pain associated with diabetes (diabetic peripheral neuropathy).May be used to relieve symptoms of anxiety in adults and children aged over 7 years with generalized anxiety disorder.Used in the treatment of moderate-to-severe depression (Major Depressive Disorder).Cymbalta belongs to a group of medicines called Selective Serotonin and Norepinephrine Reuptake Inhibitors (SSNRIs).

Experts aren't sure exactly how Cymbalta (duloxetine) works but believe its antidepressant, pain-relieving, and anti-anxiety actions are due to its ability to enhance the effects of serotonin and noradrenaline in the central nervous system.Duloxetine may be used in the treatment of depression, chronic pain, or anxiety. Cymbalta is a brand (trade) name for duloxetine.Medically reviewed by Carmen Fookes, BPharm.